Climate change is rendering the Lower Mekong River Basin (LMRB) even more vulnerable via the intensification of extreme weather events and record-exceeding floods. This project, therefore, seeks new integrated approaches to disaster risk reduction to address climate change challenges effectively and adaptively. The proposed project targets the introduction and later, mainstreaming of adaptation strategies for climate change and disaster risk reduction to LMRB via the realization of 4 objectives: (i) to model present and future potential flood damages; (ii) to estimate the joint probability distribution of insurance losses; (iii) To support developing flood risk mitigation strategies and financial potentials in enhancing LMRB’s climate change resilience; and (iv) to disseminate research findings and contribute to building stakeholders’ capacities to adopt and upscale disaster risk reduction and adaptation. Despite being among the fastest growing sustainability-related topics, flood hazard interdependencies across regions and the corresponding joint risks at the national-to-basin scale, flood protection standards, financial risk transfers, and public adaptation funds remain under-represented in climate change and disaster risk reduction, hence the verified novelty of the proposed project. The LMRB is transboundary, therefore, the project can create new multinational partnerships while strengthening the existing ones between involved universities, NGOs, and governments.