The Monsoon Asia region, which includes Southeast Asia (SEA) and South Asia, is widely known for its high levels of air pollution. The air quality assessment was conducted in this project to investigate the impact of COVID-19 pandemic lockdowns on air pollution levels by analyzing the consequences of restrictions on movement and economic activities. The investigation revealed substantial enhancements in air quality during the periods of lockdown. Significant reductions in levels of prominent pollutants such as nitrogen dioxide (NO2), which serves as an indicator for traffic-related emissions, were observed in the majority of cities. The decrease in traffic can be linked to the fact that people stayed at home and limited economic activities during the lockdown. Metropolitan areas experiencing severe traffic congestion witnessed the most substantial reductions in NO2 levels, often reaching a remarkable decline of more than 50%. The study also noted decreases in aerosol optical depth (AOD) and fine particulate matter (PM2.5), a toxic pollutant associated with respiratory problems. AOD and PM2.5 emissions commonly originate from several sources, such as vehicle exhaust, industrial operations, and biomass combustion. The implementation of lockdown measures resulted in a decline in industrial operations and vehicular movement, leading to a notable decrease in AOD and PM2.5 levels in numerous urban areas. The reductions of AOD and PM2.5 seen in certain major cities across the Monsoon Asia region up to 39%. Nevertheless, the effect of lockdowns on air quality varied around the region. Certain nations, especially those that share a border with China, continue to face pollution originating from sources that cross national boundaries. The transportation of pollutants through wind from nearby countries can hinder the efficacy of local initiatives aimed at enhancing air quality. This research provides useful insights that can be utilized by policymakers to reduce air pollutant concentrations in the Monsoon Asia region. The notable enhancements in air quality witnessed during lockdowns exemplify the noteworthy impact of human activities, namely transportation, and industry, on air pollution in the area. The air quality assessment conducted in this study by using air quality data from satellite-based and ground-based measurements were able to determine the shifting of air quality levels across the Monsoon Asia region during the implementation of COVID-19 lockdowns. The study highlights the necessity of implementing stringent strategies that can effectively enhance air quality over the region based on the implementation impacts from various types of COVID-19 control measures, especially in translating the research findings for policy development. Collaboration among different countries in the Monsoon Asia region and the exchange of information can play a vital role in addressing these air pollution challenges in a comprehensive way.