Extreme climate events, such as heavy rainfall, heat waves, and drought, have become the most common natural disasters, exacting a high toll on people and economies. As a result, their frequency and losses increase, stressing governments’ and humanitarian organizations’ response capacities. Addressing the consequences and occurrence of these disasters always has a significant challenge in the Philippines, particularly at Cagayan River Basin, due to increasing population and the impacts posed by climate change. One of the many approaches to addressing this challenge is to make better use of climate information and tailor it to predict better the probability of occurrences and associated risk for such disasters before they occur. This study is conducted to help meet these challenges considering the spatio-temporal assessment of climate change impacts on extreme climate events based on comprehensive assessment of extreme rainfall and temperature indices using data for worst-case climate change scenarios MRIAGCM3.2S. The results have shown an increased risk from the severe dry spell and wet spell in future period over CRB than past, which may lead to higher vulnerability for drought and flood.