Riverine carbon fluxes (discharge to the sea) and emission (outgassing or evasion) are an important part of carbon exchanges between terrestrial, oceanic and atmospheric environment. Carbon fluxes and emission of the river are impacted by both natural (plate margin tectonics, volcanic deposits, high elevations, steep slopes, high intensive rainfalls and etc.) and anthropogenic factors (high population density, deforestation, reservoir impoundment, intensive agriculture, and urbanization). In Asian regions, the river water discharge and sediment loads have been altered dramatically over the past decades as a result of reservoir impoundment, land use, population, and climate changes. Solid sediment loads not only directly contribute organic carbon, but also affect chemical weathering, and biological processes, thereby change carbon consumption and possible emission. The Red River (Vietnam and China) forming the Red River delta is a good example of a South-East Asian river system strongly affected by climate and human activities. In the present project, the SENEQUE/RIVERSTRAHLER model could be used for relating the carbon transfer at the scale of the whole drainage network to the constraints resulting from human activities and natural conditions in the Red River watershed.