Floodplain areas in Nepal have been prime locations for agriculture-related activities, as these areas can be easily irrigated and consist of nutrient-rich soil. However, with the expansion of agricultural infrastructure in other areas (e.g., irrigation systems, chemical fertilizers, high-yielding seeds), many of these floodplains are now abandoned due to the risks of potential flood hazards. The Government of Nepal should focus on harnessing economic opportunities in these areas. This requires tailored-made programs focusing on agriculture production, animal husbandry, fisheries, and nature-based tourism.