Climate change is one of the key issues that require significant global efforts. Vietnam has been recognised as one of the countries most vulnerable to the effects of climate change. Various APN researches have been carried out over the years on the impact of climate change on local regional communities in Vietnam and Asia Pacific neighbouring countries and how adaptive measures – especially in agriculture and forestry – have been adopted to protect the locals’ livelihood. Based on findings from such research, this guidance explains the concept and signals of climate change and the effect of climate change on upstream catchment areas such as those in Da River communities, and on their agriculture and forestry activities. It will then set out the development of climate change adaption and mitigation strategies in upland areas, with a special focus on agroforestry farming. It will explain how these strategies have been adopted by various local communities across Vietnam and other countries and/or have been recommended by scientists. The guidance’s key message is that climate change has caused much direct adverse impact on the livelihood of farmers all across Vietnam and the neighbouring countries. It is, therefore, necessary for the local stakeholders to work together to adopt suitable adaptation and mitigation strategies, of which agroforestry farming should be of particular interest.