The recent Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) Nexus Assessment evaluates the important interlinkages between biodiversity, food, health, water and climate change, showing that the world is facing interlinked crises that amplify one another and tackling them in separate silos has been ineffective and even counterproductive. The report also highlights a set of 71 “response options” (actions or policies) which provide synergistic benefits across the five sectors. In this project, we propose to examine nexus interlinkages and governance in several key locations in Southeast Asia. Through collaborative research involving scientists across four countries (the US, Vietnam, Indonesia and Myanmar), this project will uncover existing gaps in integrated sustainability planning, policy and strategies, as well as identifying promising cases of holistic management that need scaling out. Through policy mapping, stakeholder interviews and household surveys, evaluation of decision-support tools, participatory scenario planning, and other methods, the research team will provide a comprehensive understanding of nexus interlinkages in Southeast Asia. Outcomes of the research will include better understanding of the barriers and enablers of integrated policy to manage across biodiversity-water-food-health-climate, improved decision support opportunities for policymakers, and direct inputs into future IPBES and IPCC reports.