To combat the adverse climatic condition in agriculture, a sustainable production system like organic agriculture is inseparable, which stimulates and increases agro-ecosystem health, including biodiversity, biological cycles, and soil biological activity. Throughout this context, this study examined the current literature on organic agriculture’s contribution to food and water security, as well as its expansion in South Asia. Relevant research documents were retrieved using Elsevier’s Scopus database and other sources in order to do this (by applying search equations). The authors have accordingly underlined the huge scope and opportunity of organic agriculture that can contribute to ecological sustainability, especially in the developing countries of South Asia and other regions. Our assessment found that six case studies of organic agriculture have potentiality that could boost the production of quality food, proper utilization of renewable resources, maintaining long-term soil fertility, biological pest control, and efficient use of water resources. This review discussed the organic agricultural practices that secure the food and water status from a South Asian perspective.