Nature-based solutions (NbS) are increasingly recognized as important tools for moving towards a more holistic approach to using and managing water. Integrating NbS in existing water management practices, however, is an ongoing process. The book, “Regional Perspectives of Nature-based Solutions for Water: Benefits and Challenges”, provides a state-of-the-art overview of technologies and approaches for integrating NbS in water management based on experiences from across the world and a diverse range of in-depth case studies of NbS applications to urban water management in Asia. This chapter introduces and brings together the different contributions to the book, highlighting emerging challenges and opportunities for harnessing the potential of NbS in the region. Emerging experiences considered in the book suggest the need for better integration of different technologies and approaches, given the diversity of urban water challenges and the complementary benefits of different NbS. Closely related to this is also the need for integrated approaches to monitoring and assessing the impacts of existing practices as a basis for enhancing their technical performance, sustainability and co-benefits. Recent methodological advances in the design, implementation and assessment of NbS from Europe and outside could also inform the development of more effective approaches to stakeholder engagement, biodiversity generation, financing and learning from NbS.