Countering climate challenges requires genuine multi-layered approaches in cooperation with various stakeholders. Spanning 20 years, the Asia-Pacific Network for Global Change Research (APN) has been facilitating the research community to provide regional and grassroots results and solutions, while acting as a mechanism to encourage science-policy-stakeholder dialogue. This paper outlines the relevance of APN projects to IPCC policymaking by laying out knowledge products and lessons learned from the projects. It also narrates how regional research and capacity building assist in responding to the increasing urgency across climate change and the SDGs. A synthesis of project-generated knowledge was garnered from research and capacity development studies conducted under the auspices of APN to identify their scope and level of policy relevance. A combined typology and solution scanning with Likert scale as relevance rating was employed to categorize contribution against key themes of the IPCC sixth assessment report. Findings suggest 115 distinct and relevant projects completed mostly in Southeast Asia, South Asia and Temperate East Asia, with many of them asserting community-based adaptation and mitigation surrounding issues on ecosystems and biodiversity, extreme weather events, water-food-energy nexus, sustainable waste management, and climate education. Findings also show 163 knowledge products in which majority of them (66.87%) were peer-reviewed journal articles, 11.04% were reports, 7.98% were policy briefs, 6.75% were guidelines and tools, 4.91% were books and 2.45% were perspectives and opinions. With the evolving synergies between global climate targets and the SDGs, it is recommended that APN solidify its role in science-policy partnerships and networking by creating improved interlinkages for disseminating knowledge gaps filled and in replicating lessons learned and best practices found in APN knowledge products. In addition to science-policy dialogues and output synthesis, a regular review of APN research and capacity development outcomes will help in realizing these important aspects toward wider policy impact.