Study on seismic hazard, building vulnerability and human loss assessment become substantial for building education institutions since the building are used by a lot of students, lecturers, researchers, and guests. The University of the Philippines, Los Banos (UPLB) located in an earthquake prone area. The earthquake could cause structural damage and injury of the UPLB community. We have conducted earthquake assessment in different magnitude and time to predict the posibility of ground shaking, building vulnerability and estimated the number of casualty of the UPLB community. The data preparation in this study includes the earthquake scenario modeling using Intensity Prediction Equations (IPEs) for shallow crustal shaking attenuation to produce intensity map of bedrock and surface. Earthquake model was generated from the segment IV and the segment X of the Valley Fault System (VFS). Building vulnerability of different type of building was calculated using fragility curve of the Philippines building. The population data for each building in various occupancy time, damage ratio, and injury ratio data were used to compute the number of casualties. The result reveals that earthquake model from the segment IV and the segment X of the VFS could generate earthquake intensity between 7.6 – 8.1 MMI in the UPLB campus. The 7.7 Mw earthquake (scenario I) from the segment IV could cause 32% – 51% damage of building and 6.5 Mw earthquake (scenario II) occurring in the segment X could cause 18% – 39% structural damage of UPLB buildings. If the earthquake occurs at 2 PM (day-time), it could injure 10.2% – 18.8% for the scenario I and could injure 7.2% – 15.6% of UPLB population in scenario II. The 5 Pm event, predicted will injure 5.1%-9.4% in the scenario I, and 3.6%-7.8% in scenario II. A nighttime event (2 Am) cause injury to students and guests who stay in dormitories. The earthquake is predicted to injure 13 – 66 students and guests in the scenario I and 9 – 47 people in the scenario II. To reduce the number of injuries, the authority of UPLB have to carry out the buildings restoration, set up earthquake early warning system in all dormitories, and evacuation sign board.